William C Shakespeare Selected Research

AP23236

9/2003

Novel bone-targeted Src tyrosine kinase inhibitor drug discovery.

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William C Shakespeare Research Topics

Disease

15	Neoplasms (Cancer) 11/2016 - 09/2003
8	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 03/2012 - 10/2004
5	Osteoporosis 02/2008 - 09/2003
4	Bone Resorption 02/2008 - 09/2003
4	Bone Diseases (Bone Disease) 10/2006 - 09/2003
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 12/2011
2	Lung Neoplasms (Lung Cancer) 11/2016 - 05/2011
2	Lymphoma (Lymphomas) 01/2016 - 05/2011
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2011 - 07/2005
2	Adenocarcinoma 01/2006 - 12/2005
2	Neoplasm Metastasis (Metastasis) 12/2005 - 09/2003
1	Disease Progression 11/2016
1	Carcinogenesis 01/2016
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2016
1	Hematologic Neoplasms (Hematological Malignancy) 06/2011
1	Hypercalcemia (Milk Alkali Syndrome) 02/2008
1	Carcinoma (Carcinomatosis) 09/2006
1	Ovarian Neoplasms (Ovarian Cancer) 09/2006
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 07/2005
1	Systemic Mastocytosis 07/2005

Drug/Important Bio-Agent (IBA)

8	Phosphotransferases (Kinase)IBA 01/2016 - 07/2005
6	src-Family KinasesIBA 10/2006 - 09/2003
5	EnzymesIBA 01/2016 - 09/2003
3	Tyrosine Kinase InhibitorsIBA 01/2021 - 03/2012
3	brigatinibIBA 11/2016 - 05/2011
3	CrizotinibIBA 11/2016 - 05/2011
3	Anaplastic Lymphoma KinaseIBA 11/2016 - 12/2011
3	Adenosine Triphosphate (ATP)IBA 02/2013 - 09/2003
3	ponatinibIBA 03/2012 - 11/2009
3	Imatinib Mesylate (Gleevec)FDA Link 01/2011 - 06/2006
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2010 - 09/2006
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2016 - 05/2011
2	Pharmaceutical PreparationsIBA 10/2006 - 09/2003
2	Diphosphonates (Bisphosphonates)IBA 10/2006 - 09/2003
2	AP23846IBA 09/2006 - 12/2005
2	Interleukin-8 (Interleukin 8)IBA 01/2006 - 12/2005
1	mobocertinibIBA 01/2021
1	Antineoplastic Agents (Antineoplastics)IBA 01/2016
1	Choline KinaseIBA 01/2016
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2016
1	Phosphorylcholine (Phosphocholine)IBA 01/2016
1	Lactic Acid (Lactate)FDA LinkGeneric 02/2013
1	Lactate Dehydrogenase 5IBA 02/2013
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 03/2012
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 06/2011
1	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 06/2011
1	NVP-TAE684IBA 05/2011
1	nilotinib FDA Link 11/2009
1	Dasatinib (BMS 354825)FDA Link 11/2009
1	AP 24163IBA 08/2009
1	AP 23451IBA 02/2008
1	Docetaxel (Taxotere)FDA Link 09/2006
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 09/2006
1	NF-kappa B (NF-kB)IBA 01/2006
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2005
1	Biological ProductsIBA 12/2005
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2005
1	AP23848IBA 07/2005
1	AP23464IBA 07/2005
1	bcr-abl Fusion ProteinsIBA 10/2004
1	AP22408IBA 09/2003
1	LigandsIBA 09/2003
1	PurinesIBA 09/2003
1	Alendronate (Alendronate Sodium)FDA LinkGeneric 09/2003
1	Zoledronic Acid (Zometa)FDA Link 09/2003
1	AP23236IBA 09/2003

Therapy/Procedure

6	Therapeutics 01/2016 - 09/2003
1	Oral Administration 08/2009